震颤素

**震颤素**
臨床資料
ATC碼	未分配;
识别信息
	IUPAC命名法 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine; ;
CAS号	51-73-0
PubChem CID	5534;
ChemSpider	5333;
UNII	U817VZ1URQ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID00199004 ;
化学信息
化学式	C12H20N2
摩尔质量	192.31 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C2CCCN2CC#CCN1CCCC1;
	InChI InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2; Key:JSUAJTLKVREZHV-UHFFFAOYSA-N;

震颤素（英語：Tremorine）是一种在科学研究中使动物产生震颤的药物。这种物质被用于开发治疗帕金森病的药物，因为震颤是帕金森病的主要症状之一。^[1]^[2]^[3]^[4]^[5]β受体阻滞剂也能有效抵消震颤素的影响。^[6]

震颤素是由埃弗里特等人于1956—57年首先报道的。^[7]^[8]^[9]^[10]

参见[编辑]

氧代震颤素

参考资料[编辑]

^ Trautner EM, Gershon S. Use of tremorine for screening anti-parkinsonian drugs. Nature. May 1959, 183 (4673): 1462–3. Bibcode:1959Natur.183.1462T. PMID 13657170. S2CID 4173699. doi:10.1038/1831462a0.
^ Friedman AH, Aylesworth RJ, Friedman G. Tremorine: Its Effect on Amines of the Central Nervous System. Science. September 1963, 141 (3586): 1188–90. Bibcode:1963Sci...141.1188F. PMID 14043364. S2CID 37472968. doi:10.1126/science.141.3586.1188.
^ Menon M, Clark WG, Aures D. Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats. Pharmacological Research Communications. 1971, 3 (4): 345–350. doi:10.1016/0031-6989(71)90005-1.
^ Shinozaki H, Hirate K, Ishida M. Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency. Experimental Neurology. May 1985, 88 (2): 303–15. PMID 3987859. S2CID 7607662. doi:10.1016/0014-4886(85)90193-1.
^ Morais LC, Quintans-Júnior LJ, Franco CI, Almeida JR, Almeida RN. Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology. Pharmacology, Biochemistry, and Behavior. December 2004, 79 (4): 745–9. PMID 15582683. S2CID 28371865. doi:10.1016/j.pbb.2004.10.004.
^ Paul V. The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists. Indian Journal of Physiology and Pharmacology. 1986, 30 (4): 307–12. PMID 2883120.
^ Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."
^ Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.
^ Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.
^ Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.

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[1] Trautner EM, Gershon S. Use of tremorine for screening anti-parkinsonian drugs. Nature. May 1959, 183 (4673): 1462–3. Bibcode:1959Natur.183.1462T. PMID 13657170. S2CID 4173699. doi:10.1038/1831462a0.

[2] Friedman AH, Aylesworth RJ, Friedman G. Tremorine: Its Effect on Amines of the Central Nervous System. Science. September 1963, 141 (3586): 1188–90. Bibcode:1963Sci...141.1188F. PMID 14043364. S2CID 37472968. doi:10.1126/science.141.3586.1188.

[3] Menon M, Clark WG, Aures D. Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats. Pharmacological Research Communications. 1971, 3 (4): 345–350. doi:10.1016/0031-6989(71)90005-1.

[4] Shinozaki H, Hirate K, Ishida M. Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency. Experimental Neurology. May 1985, 88 (2): 303–15. PMID 3987859. S2CID 7607662. doi:10.1016/0014-4886(85)90193-1.

[5] Morais LC, Quintans-Júnior LJ, Franco CI, Almeida JR, Almeida RN. Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology. Pharmacology, Biochemistry, and Behavior. December 2004, 79 (4): 745–9. PMID 15582683. S2CID 28371865. doi:10.1016/j.pbb.2004.10.004.

[6] Paul V. The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists. Indian Journal of Physiology and Pharmacology. 1986, 30 (4): 307–12. PMID 2883120.

[7] Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."

[8] Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.

[9] Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.

[10] Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.

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